Yes it works in any PCI-E board, and acts just like a normal XT until its paired up with a slave, but its a bit pointless getting the mastercard for a normal board, and not an Xfire one if your not going Xfire, as the normal XT is cheaper than the mastercard.
Unless you are going to go Xfire with it further down the line, and so will be getting the Xfire mobo then, then id say go for it.
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