I used to run Server 2012, then 2016 then finally 2019 on mine, but the last time I rebuilt it I just stuck Windows 10 on it and installed the Hyper-V feature.
I then just imported my old VM's for Plex, Torrents, Sharing and Testing so nothing stopping you from doing the same.
I'd run the host OS as bare as possible and then if something does go wrong you don't have to set anything special up as everything is held on a VM.
As above, I'd also look at the Stablebit stuff as it will do stuff like data duplication so your important files are on more than one drive and data recovery is a piece of cake..